Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
Read More
9
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Read More
9
NAD restoration improves heart attack recovery
We explored the potential benefits of nicotinamide riboside (NR) for heart attack recovery in a study using mice. After inducing a heart attack, we administered NR daily for seven days.
The results were promising, showing a significant increase in survival rates from 61% to 92% as NR helped restore essential coenzyme levels in the heart.
Overall, our findings suggest that NR might play a protective role in heart attack management by improving heart function and reducing inflammation.
The results were promising, showing a significant increase in survival rates from 61% to 92% as NR helped restore essential coenzyme levels in the heart.
Overall, our findings suggest that NR might play a protective role in heart attack management by improving heart function and reducing inflammation.
Read More
Most Useful Reviews
9
Homocysteine reduction
59 people found this helpful
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
Read More
9
Improves heart function
1 people found this helpful
This effectively reduces homocysteine for heart disease risk. Take it with Jarrow TMG, and it may normalise within two months. Just avoid coffee or tea when taking it.
Read More
7.5
Calms arrhythmia
When I take it, my heart arrhythmia calms down, which is beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
- All Researches
9
We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
Read More
9
NAD restoration improves heart attack recovery
We explored the potential benefits of nicotinamide riboside (NR) for heart attack recovery in a study using mice. After inducing a heart attack, we administered NR daily for seven days.
The results were promising, showing a significant increase in survival rates from 61% to 92% as NR helped restore essential coenzyme levels in the heart.
Overall, our findings suggest that NR might play a protective role in heart attack management by improving heart function and reducing inflammation.
The results were promising, showing a significant increase in survival rates from 61% to 92% as NR helped restore essential coenzyme levels in the heart.
Overall, our findings suggest that NR might play a protective role in heart attack management by improving heart function and reducing inflammation.
Read More
9
We examined how benfotiamine could help protect hearts from damage due to acute myocardial infarction. In a rat model, heart injury was induced using isoproterenol. Benfotiamine was given both before and after this treatment to see if it could reduce the damage.
While we observed significant improvements in heart enzyme levels and oxidative stress markers with benfotiamine treatment, the study focused on rats and may not directly translate to humans. Overall, benfotiamine shows promise for future cardiovascular therapies, but more research is needed.
While we observed significant improvements in heart enzyme levels and oxidative stress markers with benfotiamine treatment, the study focused on rats and may not directly translate to humans. Overall, benfotiamine shows promise for future cardiovascular therapies, but more research is needed.
Read More
9
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Read More
9
We explored the potential of targeting folate receptors with specialized exosomes to treat myocardial infarction, commonly known as a heart attack. The study centered around an innovative injectable hydrogel made from silk fibroin and alginate, designed to temporarily hold and release these folate-targeted exosomes. This combination aimed to improve heart healing after a damaging episode of myocardial ischemia/reperfusion.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Our findings showed that administering this hydrogel loaded with folate receptor-targeted exosomes significantly improved heart function in affected rats. We observed enhanced metrics such as ejection fraction and fractional shortening, coupled with reduced fibrosis in the cardiac tissue. Furthermore, molecular analysis indicated an increase in heart health markers while simultaneously reducing markers associated with fibrosis.
This study highlights the promising role of exosomes in heart treatment. However, we should note that it's difficult to isolate the specific effects of folate from the overall mechanism of the composite treatment.Overall, the results support the idea that these targeted exosomes can contribute to better heart recovery post-infarction, marking an exciting step forward in cardiac therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Homocysteine reduction
59 people found this helpful
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
Read More
9
Improves heart function
1 people found this helpful
This effectively reduces homocysteine for heart disease risk. Take it with Jarrow TMG, and it may normalise within two months. Just avoid coffee or tea when taking it.
Read More
7.5
Calms arrhythmia
When I take it, my heart arrhythmia calms down, which is beneficial.
Read More
7.5
Supports cardiovascular health
It noticeably calms my nervous system and adds energy, which is necessary for my heart problems.
Read More
7.5
Normal heart rate
After a week of taking it, my heart rate is normal. I feel good for now and anticipate more benefits.
Read More
Frequently Asked Questions
7.5
Normal heart rate
After a week of taking it, my heart rate is normal. I feel good for now and anticipate more benefits.
9
Improves heart function
1 people found this helpful
This effectively reduces homocysteine for heart disease risk. Take it with Jarrow TMG, and it may normalise within two months. Just avoid coffee or tea when taking it.
7.5
Calms arrhythmia
When I take it, my heart arrhythmia calms down, which is beneficial.
9
Homocysteine reduction
59 people found this helpful
Does it really work? I took this to lower my homocysteine, which can damage blood vessels and increase the risk of heart attack. My levels dropped from 9.3 to 5.5, which is excellent. It's essential for women planning to conceive, though not all doctors mention it.
7.5
Supports cardiovascular health
It noticeably calms my nervous system and adds energy, which is necessary for my heart problems.
7.5
Supports blood circulation
1 people found this helpful
My mum was prescribed vitamin B to normalise blood circulation. This complex has all the required B vitamins and methyl folate, making it easy to take. We highly recommend it!
9
We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.
9
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
7
We investigated how folic acid (FA) could protect against heart injury caused by isoprenaline (ISO) in rats. Over a week, the rats were given FA before being exposed to ISO, which is known to induce heart muscle damage.
The results showed that FA pretreatment helped reduce the harmful effects of ISO. It lowered markers of heart damage and oxidative stress, suggesting that FA may serve as a gentle antioxidant with potential cardiovascular benefits.
The results showed that FA pretreatment helped reduce the harmful effects of ISO. It lowered markers of heart damage and oxidative stress, suggesting that FA may serve as a gentle antioxidant with potential cardiovascular benefits.
7
We explored the effectiveness of vitamin B6 in preventing heart attacks through a systematic review and meta-analysis of randomized controlled trials. This involved analyzing data from 50 studies that included nearly 300,000 participants. Our findings indicated that supplementation with vitamin B6 showed a small decrease in the risk of major cardiovascular events; however, this effect appeared primarily in studies deemed to be of lower quality.
Interestingly, while some studies suggested a potential link between vitamin B6 and a reduced risk of cardiovascular death, these benefits predominantly surfaced in trials supported by the pharmaceutical industry. In conclusion, it's important to highlight that there was no consistent evidence to support the use of vitamin B6 or other vitamin and antioxidant supplements in preventing heart disease overall. The results need careful interpretation, especially given that the beneficial effects reported were less convincing in high-quality trials.
Overall, our assessment suggests that while vitamin B6 might have some minor beneficial aspects regarding heart attack risk, the broader implications for using such supplements in heart disease prevention remain unclear and unsubstantiated.
Interestingly, while some studies suggested a potential link between vitamin B6 and a reduced risk of cardiovascular death, these benefits predominantly surfaced in trials supported by the pharmaceutical industry. In conclusion, it's important to highlight that there was no consistent evidence to support the use of vitamin B6 or other vitamin and antioxidant supplements in preventing heart disease overall. The results need careful interpretation, especially given that the beneficial effects reported were less convincing in high-quality trials.
Overall, our assessment suggests that while vitamin B6 might have some minor beneficial aspects regarding heart attack risk, the broader implications for using such supplements in heart disease prevention remain unclear and unsubstantiated.
References
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. 10.1016/j.ejphar.2025.177413
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. 10.1556/2060.2023.00291
- Tannous C, Ghali R, Karoui A, Habeichi NJ, Amin G, et al. Nicotinamide Riboside Supplementation Restores Myocardial Nicotinamide Adenine Dinucleotide Levels, Improves Survival, and Promotes Protective Environment Post Myocardial Infarction. Cardiovasc Drugs Ther. 2024;38:1385. 10.1007/s10557-023-07525-1
- Zhang B, Dong H, Xu Y, Xu D, Sun H, et al. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77:299. 10.1038/s41430-022-01206-2
- Khan A, Iqubal A, Wasim M, Syed MA, Haque SE. D-pinitol attenuates isoproterenol-induced myocardial infarction by alleviating cardiac inflammation, oxidative stress and ultrastructural changes in Swiss albino mice. Clin Exp Pharmacol Physiol. 2022;49:1232. 10.1111/1440-1681.13703
- Evens L, Beliën H, D'Haese S, Haesen S, Verboven M, et al. Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?. Int J Mol Sci. 2021;22. 10.3390/ijms22179266
- Ahmed LA, Hassan OF, Galal O, Mansour DF, El-Khatib A. Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats. PLoS One. 2020;15:e0232413. 10.1371/journal.pone.0232413
- Hodzic E. Potential Anti-Inflammatory Treatment of Ischemic Heart Disease. Med Arch. 2018;72:94. 10.5455/medarh.2018.72.94-98
- Deluyker D, Ferferieva V, Driesen RB, Verboven M, Lambrichts I, et al. Pyridoxamine improves survival and limits cardiac dysfunction after MI. Sci Rep. 2017;7:16010. 10.1038/s41598-017-16255-y
- Ding YP, Pedersen EK, Johansson S, Gregory JF, Ueland PM, et al. B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris. Nutr Metab Cardiovasc Dis. 2016;26:495. 10.1016/j.numecd.2015.12.009
- Myung SK, Ju W, Cho B, Oh SW, Park SM, et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2013;346:f10. 10.1136/bmj.f10
- Ni Y, Hua Y, He Z, Hu W, Chen Z, et al. Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction. J Biomater Appl. 2024;39:139. 10.1177/08853282241251610
- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. 10.1371/journal.pone.0275956
- Twum F, Morte N, Wei Y, Nkemjika S, Liu F, et al. Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort. Hypertens Res. 2020;43:938. 10.1038/s41440-020-0482-5
- Saad Shaukat MH, Toledo-Garcia A, Torosoff M. Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet's Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C). Cureus. 2019;11:e5344. 10.7759/cureus.5344
- Borowczyk K, Piechocka J, Głowacki R, Dhar I, Midtun Ø, et al. Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial. J Intern Med. 2019;285:232. 10.1111/joim.12834
